|
KMID : 0525720180230010015
|
|
Journal of Chitin and Chitosan
2018 Volume.23 No. 1 p.15 ~ p.22
|
|
|
Observation of Drug Release Behavior, Physicochemical Properties and Cytotoxicity Changes in the Stent according to Functional Group Ratio of Cellulose Acetate Butyrate
|
|
Jang Bu-Nam
Kang Sung-Nam
Kum Chang-Hun
|
|
|
Abstract
|
|
|
|
Although drug eluting stent effectively reduce restenosis compared to bare metal stent, it still has the side effect of the drug, which are continuously caused after the interventional procedure of the coronary artery stent, such as delayed re-endothelialization and thrombosis induced by hypersensitivity of drug and inflammation. In order to solve this problem, a controlled drug release profile was able to induce re-endothelialization of vessel sufficiently by minimizing the side effect of drug. In this study, we investigated drug release behavior, physico-chemical characteristics and cytotoxicity of the stent prepared according to the ratio of butyrate functional group of cellulose acetate butyrate (CAB) in order to demonstrate the possibility of minimizing side effect of drug. CAB exhibits hydrophobic properties as the ratio of butyrate functional groups increases. The drug release rate of high butyrate group decreased about 1.5-3.8 times compared with low butyrate group in case of hydrophobic drug such as paclitaxel. The cytotoxicity was confirmed by the MTT assay. The cell viability in high butyrate group increased about 29% compared to low butyrate group. These results indicate drug release profile was able to controlled by the ratio of the butyrate functional group in CAB. In addition, it suggests that it can be used as a factor to minimize secondary adverse effects such as delayed reendothelialization and thrombosis through inhibition of hypersensitivity and toxicity induced by drug continuously.
|
|
|
KEYWORD
|
|
|
Drug-eluting stent, Drug-controlled release, CAB, Paclitaxel, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|